1-(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy-3,4-dinitrobenzene → 4-(6-((3-Methyl-1,2,4-oxadiazol-5-yl)methoxy)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-5-yl)benzamide

HRID 2284283Notes

Reaction equation

HRID 2284283 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([N+:18]([O-])=O)[CH:10]=2)[O:4][N:3]=1.[NH:21]1[C:29]2[C:24](=[CH:25][C:26]([NH:30][C:31]([C:33]3[CH:40]=[CH:39][C:36]([CH:37]=O)=[CH:35][CH:34]=3)=[O:32])=[CH:27][CH:28]=2)[CH:23]=[CH:22]1>>[CH3:1][C:2]1[N:6]=[C:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]3[N:15]=[C:37]([C:36]4[CH:35]=[CH:34][C:33]([C:31]([NH:30][C:26]5[CH:25]=[C:24]6[C:29](=[CH:28][CH:27]=5)[NH:21][CH:22]=[CH:23]6)=[O:32])=[CH:40][CH:39]=4)[NH:18][C:11]=3[CH:10]=2)[O:4][N:3]=1

Participants

3

Reactant 2

HCID 866740061-(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy-3,4-dinitrobenzeneHCID 866740164-(5-Indolylaminocarbonyl)benzaldehyde

Product 1

HCID 676873634-(6-((3-Methyl-1,2,4-oxadiazol-5-yl)methoxy)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-5-yl)benzamide

Procedure

Compound 659 was prepared according to the procedure similar to that described in Scheme III from 1-(3-methyl-1,2,4-oxadiazol-5-yl)methoxy-3,4-dinitrobenzene and 4-(5-indolylaminocarbonyl)benzaldehyde. [M+H]+ calcd for C26H20N6O3: 465.16; found: 464.98.

Sources & evidence

ORD record
ord-f314500bd63d46b3b633984af1972bf1
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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