2-Methoxyethoxy-3,4-dinitrobenzene → 4-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(2-oxoindolin-5-yl)benzamide

HRID 2284289Notes

Reaction equation

HRID 2284289 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]([N+:15]([O-])=O)[CH:7]=1.[O:18]=[C:19]1[CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([NH:28][C:29]([C:31]3[CH:38]=[CH:37][C:34]([CH:35]=O)=[CH:33][CH:32]=3)=[O:30])[CH:25]=2)[NH:20]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]2[N:12]=[C:35]([C:34]3[CH:33]=[CH:32][C:31]([C:29]([NH:28][C:24]4[CH:25]=[C:26]5[C:21](=[CH:22][CH:23]=4)[NH:20][C:19](=[O:18])[CH2:27]5)=[O:30])=[CH:38][CH:37]=3)[NH:15][C:8]=2[CH:7]=1

Participants

3

Reactant 2

HCID 866740102-Methoxyethoxy-3,4-dinitrobenzeneHCID 866740194-((2-Oxoindolin-5-yl)aminocarbonyl)benzaldehyde

Product 1

HCID 676868834-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(2-oxoindolin-5-yl)benzamide

Procedure

Compound 666 was prepared according to the procedure similar to that described in Scheme III from 1-(2-methoxyethoxy-3,4-dinitrobenzene and 4-((2-oxoindolin-5-yl)aminocarbonyl)benzaldehyde. [M+H]+ calcd for C25H22N4O4: 443.16; found: 443.05.

Sources & evidence

ORD record
ord-40d52b8eaaf64659a50f252f69b0da81
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

Loading…