4-(6-Indolylaminocarbonyl)benzaldehyde → 4-(6-(2-Hydroxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-6-yl)benzamide

HRID 2284291Notes

Reaction equation

HRID 2284291 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([N+:14]([O-])=O)[CH:6]=1.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([NH:26][C:27]([C:29]3[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=3)=[O:28])[CH:24]=2)[CH:19]=[CH:18]1>>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]2[N:11]=[C:33]([C:32]3[CH:31]=[CH:30][C:29]([C:27]([NH:26][C:23]4[CH:24]=[C:25]5[C:20]([CH:19]=[CH:18][NH:17]5)=[CH:21][CH:22]=4)=[O:28])=[CH:36][CH:35]=3)[NH:14][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 866740144-(6-Indolylaminocarbonyl)benzaldehydeHCID 866740201-(2-Hydroxyethoxy)-3,4-dinitrobenzene

Product 1

HCID 676869654-(6-(2-Hydroxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-6-yl)benzamide

Procedure

Compound 672 was prepared according to the procedure similar to that described in Scheme III from 1-(2-hydroxyethoxy)-3,4-dinitrobenzene and 4-(6-indolylaminocarbonyl)benzaldehyde. [M+H]+ calcd for C24H20N4O3: 413.15; found: 412.96.

Sources & evidence

ORD record
ord-b474737acc38487f85e9070b5dedb48f
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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