2-Methoxyethoxy-3,4-dinitrobenzene → 4-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1-(2-hydroxyethyl)indol-5-yl)benzamide

HRID 2284292Notes

Reaction equation

HRID 2284292 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]([N+:15]([O-])=O)[CH:7]=1.[OH:18][CH2:19][CH2:20][N:21]1[C:29]2[C:24](=[CH:25][C:26]([NH:30][C:31]([C:33]3[CH:40]=[CH:39][C:36]([CH:37]=O)=[CH:35][CH:34]=3)=[O:32])=[CH:27][CH:28]=2)[CH:23]=[CH:22]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]2[N:12]=[C:37]([C:36]3[CH:35]=[CH:34][C:33]([C:31]([NH:30][C:26]4[CH:25]=[C:24]5[C:29](=[CH:28][CH:27]=4)[N:21]([CH2:20][CH2:19][OH:18])[CH:22]=[CH:23]5)=[O:32])=[CH:40][CH:39]=3)[NH:15][C:8]=2[CH:7]=1

Participants

3

Reactant 2

HCID 866740102-Methoxyethoxy-3,4-dinitrobenzeneHCID 866740214-(1-(2-Hydroxyethyl)-5-indolylaminocarbonyl)benzaldehyde

Product 1

HCID 676869354-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1-(2-hydroxyethyl)indol-5-yl)benzamide

Procedure

Compound 674 was prepared according to the procedure similar to that described in Scheme III from 1-(2-methoxyethoxy-3,4-dinitrobenzene and 4-(1-(2-hydroxyethyl)-5-indolylaminocarbonyl)benzaldehyde. [M+H]+ calcd for C27H26N4O4: 471.20; found: 471.05.

Sources & evidence

ORD record
ord-8957144974c74d6b964a91763c737a0c
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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