2-Methoxyethoxy-3,4-dinitrobenzene → 4-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1-(2-methoxyethyl)-2-methylindol-5-yl)benzamide

HRID 2284293Notes

Reaction equation

HRID 2284293 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]([N+:15]([O-])=O)[CH:7]=1.[CH3:18][O:19][CH2:20][CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([NH:31][C:32]([C:34]3[CH:41]=[CH:40][C:37]([CH:38]=O)=[CH:36][CH:35]=3)=[O:33])=[CH:28][CH:29]=2)[CH:24]=[C:23]1[CH3:42]>>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]2[N:12]=[C:38]([C:37]3[CH:36]=[CH:35][C:34]([C:32]([NH:31][C:27]4[CH:26]=[C:25]5[C:30](=[CH:29][CH:28]=4)[N:22]([CH2:21][CH2:20][O:19][CH3:18])[C:23]([CH3:42])=[CH:24]5)=[O:33])=[CH:41][CH:40]=3)[NH:15][C:8]=2[CH:7]=1

Participants

3

Reactant 2

HCID 866740102-Methoxyethoxy-3,4-dinitrobenzeneHCID 866740224-(1-(2-Methoxyethyl)2-methyl-5-indolylaminocarbonyl)benzaldehyde

Product 1

HCID 676868084-(6-(2-Methoxyethoxy)-1H-benzo[d]imidazol-2-yl)-N-(1-(2-methoxyethyl)-2-methylindol-5-yl)benzamide

Procedure

Compound 675 was prepared according to the procedure similar to that described in Scheme III from 1-(2-methoxyethoxy-3,4-dinitrobenzene and 4-(1-(2-methoxyethyl)-2-methyl-5-indolylaminocarbonyl)benzaldehyde. [M+H]+ calcd for C29H30N4O4: 499.24; found: 499.06.

Sources & evidence

ORD record
ord-3936d44e75fb4fd8ac2d7bda2d78adc8
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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