HRID2284295

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15655

Cyclopropane carboxylic acid

C4H6O2

HCID18617591

4-(4-Hydroxy-1-piperidinyl)benzoic acid

C12H15NO3

HCID67112580

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc2nn(-c3ccc(NC(=O)C4CC4)cc3)cc2c1)c1ccc(N2CCC(O)CC2)cc1

HCID67113641

未命名化合物

PROCEDURE

实验过程

Compound 681 was prepared according to the procedure similar to that described in Scheme IV from 4-(4-hydroxypiperidin-1-yl)benzoic acid, cyclopropanecarboxylic acid, and 2-(4-aminophenyl)-5-amino-2H-indazole. [M+H]+ calcd for C29H29N5O3: 496.23; found 496.05.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4bda7cc2f49b4df6b285cc3106cdac20
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09144557B2
来源说明: uspto-grants-2015_09

反应 SMILES

[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH:17]1([C:20]([OH:22])=O)[CH2:19][CH2:18]1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH:38]=[C:37]3[C:32]([CH:33]=[CH:34][C:35]([NH2:39])=[CH:36]3)=[N:31]2)=[CH:26][CH:25]=1>>[CH:17]1([C:20]([NH:23][C:24]2[CH:25]=[CH:26][C:27]([N:30]3[CH:38]=[C:37]4[C:32]([CH:33]=[CH:34][C:35]([NH:39][C:12](=[O:14])[C:11]5[CH:10]=[CH:9][C:8]([N:5]6[CH2:4][CH2:3][CH:2]([OH:1])[CH2:7][CH2:6]6)=[CH:16][CH:15]=5)=[CH:36]4)=[N:31]3)=[CH:28][CH:29]=2)=[O:22])[CH2:19][CH2:18]1