Cyclopropanecarboxylic acid → N-(2-(4-(Cyclopropanecarboxamido)phenyl)-2H-indazol-5-yl)-4-(4-hydroxypiperidin-1-yl)benzamide

HRID 2284295Notes

Reaction equation

HRID 2284295 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH:17]1([C:20]([OH:22])=O)[CH2:19][CH2:18]1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH:38]=[C:37]3[C:32]([CH:33]=[CH:34][C:35]([NH2:39])=[CH:36]3)=[N:31]2)=[CH:26][CH:25]=1>>[CH:17]1([C:20]([NH:23][C:24]2[CH:25]=[CH:26][C:27]([N:30]3[CH:38]=[C:37]4[C:32]([CH:33]=[CH:34][C:35]([NH:39][C:12](=[O:14])[C:11]5[CH:10]=[CH:9][C:8]([N:5]6[CH2:4][CH2:3][CH:2]([OH:1])[CH2:7][CH2:6]6)=[CH:16][CH:15]=5)=[CH:36]4)=[N:31]3)=[CH:28][CH:29]=2)=[O:22])[CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 15655Cyclopropanecarboxylic acidHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 671125805-Amino-2-(4-aminophenyl)indazole

Product 1

HCID 67113641N-(2-(4-(Cyclopropanecarboxamido)phenyl)-2H-indazol-5-yl)-4-(4-hydroxypiperidin-1-yl)benzamide

Procedure

Compound 681 was prepared according to the procedure similar to that described in Scheme IV from 4-(4-hydroxypiperidin-1-yl)benzoic acid, cyclopropanecarboxylic acid, and 2-(4-aminophenyl)-5-amino-2H-indazole. [M+H]+ calcd for C29H29N5O3: 496.23; found 496.05.

Sources & evidence

ORD record
ord-4bda7cc2f49b4df6b285cc3106cdac20
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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