Cyclopropylamine → HCID 67113301, compound

HRID 2284323Notes

Reaction equation

HRID 2284323 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=1)[C:6]([CH3:20])=[CH:5]2.[CH:21]1([NH2:24])[CH2:23][CH2:22]1.[OH:25][CH:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH2:28][CH2:27]1>>[OH:25][CH:26]1[CH2:27][CH2:28][N:29]([C:32]2[CH:40]=[CH:39][C:35]([C:36]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:19]=[CH:18][C:14]([C:15](=[O:17])[NH:24][CH:21]5[CH2:23][CH2:22]5)=[CH:13][CH:12]=3)[C:6]([CH3:20])=[CH:5]4)=[O:37])=[CH:34][CH:33]=2)[CH2:30][CH2:31]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 67112869HCID 67112869, compound

Product 1

HCID 67113301HCID 67113301, compound

Procedure

Compound 959 was prepared according to the procedure described in Scheme IV from 4-(5-amino-2-methyl-1H-indol-1-yl)benzoic acid, cyclopropaneamine, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C31H32N4O3: 509.25; found: 509.12.

Sources & evidence

ORD record
ord-7c42b5529f0a482aabde25325fcb12b0
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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