Cyclopropylamine → HCID 67113339, compound

HRID 2284324Notes

Reaction equation

HRID 2284324 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=1)[CH:6]=[CH:5]2.[CH:20]1([NH2:23])[CH2:22][CH2:21]1.[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][N:32]2[C:40]3[C:35](=[CH:36][C:37]([C:41](O)=[O:42])=[CH:38][CH:39]=3)[CH:34]=[CH:33]2)[CH2:26][CH2:25]1>>[CH:20]1([NH:23][C:15]([C:14]2[CH:13]=[CH:12][C:11]([N:7]3[C:8]4[C:4](=[CH:3][C:2]([NH:1][C:41]([C:37]5[CH:36]=[C:35]6[C:40](=[CH:39][CH:38]=5)[N:32]([CH2:31][CH2:30][N:27]5[CH2:26][CH2:25][O:24][CH2:29][CH2:28]5)[CH:33]=[CH:34]6)=[O:42])=[CH:10][CH:9]=4)[CH:5]=[CH:6]3)=[CH:19][CH:18]=2)=[O:16])[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 63749289HCID 63749289, compoundHCID 67112874HCID 67112874, compound

Product 1

HCID 67113339HCID 67113339, compound

Procedure

Compound 960 was prepared according to the procedure described in Scheme IV from 4-(5-amino-1H-indol-1-yl)benzoic acid, cyclopropaneamine, and 1-(2-morpholinoethyl)-1H-indole-5-carboxylic acid. [M+H]+ calcd for C33H33N5O3: 548.26; found 548.13.

Sources & evidence

ORD record
ord-a1d2b6f827fb4f389f9fa7b553338763
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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