4-(4-Hydroxy-1-piperidinyl)benzoic acid → HCID 67112950, compound

HRID 2284330Notes

Reaction equation

HRID 2284330 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)=[N:7][NH:8]2)=[CH:4][CH:3]=1.[OH:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=2)[CH2:21][CH2:20]1>>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:6]2[C:5]3[C:9](=[CH:10][C:2]([NH:1][C:29](=[O:30])[C:28]4[CH:27]=[CH:26][C:25]([N:22]5[CH2:23][CH2:24][CH:19]([OH:18])[CH2:20][CH2:21]5)=[CH:33][CH:32]=4)=[CH:3][CH:4]=3)[NH:8][N:7]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 67112717HCID 67112717, compound

Product 1

HCID 67112950HCID 67112950, compound

Procedure

Compound 976 was prepared according to the procedure described in Scheme IV from 6-amino-3-(4-aminophenyl)-1H-indazole, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C25H25N5O2: 428.20; found 428.07.

Sources & evidence

ORD record
ord-52258cbe9ec44a43bcecd67bca30dad7
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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