1-Methyl-2-pyrrolecarboxylic acid → HCID 67113225, compound

HRID 2284332Notes

Reaction equation

HRID 2284332 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:20][N:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:26]([OH:28])=O.[OH:29][CH:30]1[CH2:35][CH2:34][N:33]([C:36]2[CH:42]=[CH:41][C:39]([NH2:40])=[CH:38][CH:37]=2)[CH2:32][CH2:31]1>>[OH:29][CH:30]1[CH2:31][CH2:32][N:33]([C:36]2[CH:42]=[CH:41][C:39]([NH:40][C:15]([C:14]3[CH:18]=[CH:19][C:11]([C:6]4[C:5]5[C:9](=[CH:10][C:2]([NH:1][C:26]([C:22]6[N:21]([CH3:20])[CH:25]=[CH:24][CH:23]=6)=[O:28])=[CH:3][CH:4]=5)[NH:8][CH:7]=4)=[CH:12][CH:13]=3)=[O:16])=[CH:38][CH:37]=2)[CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 814531-Methyl-2-pyrrolecarboxylic acidHCID 167921071-(4-Aminophenyl)piperidin-4-olHCID 67113048HCID 67113048, compound

Product 1

HCID 67113225HCID 67113225, compound

Procedure

Compound 981 was prepared according to the procedure described in Scheme IV from 4-(6-amino-1H-indol-3-yl)benzoic acid, 1-methylpyrrole-2-carboxylic acid, and 4-(4-hydroxypiperidin-1-yl)aniline. [M+H]+ calcd for C32H31N5O3: 534.15; found: 534.09.

Sources & evidence

ORD record
ord-de031080d606451aaaedefedcf36bbb6
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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