Cyclopropylamine → HCID 67113598, compound

HRID 2284333Notes

Reaction equation

HRID 2284333 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=1)[CH:6]=[C:5]2[C:20](=[O:22])[CH3:21].[CH:23]1([NH2:26])[CH2:25][CH2:24]1.[OH:27][CH:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[OH:27][CH:28]1[CH2:29][CH2:30][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:12]=[CH:13][C:14]([C:15](=[O:17])[NH:26][CH:23]5[CH2:25][CH2:24]5)=[CH:18][CH:19]=3)[CH:6]=[C:5]4[C:20](=[O:22])[CH3:21])=[O:39])=[CH:36][CH:35]=2)[CH2:32][CH2:33]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 67112550HCID 67112550, compound

Product 1

HCID 67113598HCID 67113598, compound

Procedure

Compound 984 was prepared according to the procedure described in Scheme IV from 4-(5-amino-3-acetyl-1H-indol-1-yl)benzoic acid, cyclopropaneamine, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C32H32N4O4: 537.24; found: 537.06.

Sources & evidence

ORD record
ord-97b33ab595e84a1c9403ccefbd0a4256
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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