Cyclopropylamine → HCID 67113327, compound

HRID 2284334Notes

Reaction equation

HRID 2284334 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[CH:20]1([NH2:23])[CH2:22][CH2:21]1.[OH:24][CH:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=2)[CH2:27][CH2:26]1>>[OH:24][CH:25]1[CH2:26][CH2:27][N:28]([C:31]2[CH:39]=[CH:38][C:34]([C:35]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:12]=[CH:13][C:14]([C:15](=[O:17])[NH:23][CH:20]5[CH2:22][CH2:21]5)=[CH:18][CH:19]=3)[N:6]=[CH:5]4)=[O:36])=[CH:33][CH:32]=2)[CH2:29][CH2:30]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 67113165HCID 67113165, compound

Product 1

HCID 67113327HCID 67113327, compound

Procedure

Compound 985 was prepared according to the procedure described in Scheme IV from 4-(5-amino-1H-indazol-1-yl)benzoic acid, cyclopropaneamine, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C29H29N5O3: 496.23; found 496.09.

Sources & evidence

ORD record
ord-d7719dcd9c254962ba8b0701967d828d
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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