4-(4-Hydroxy-1-piperidinyl)benzoic acid → HCID 67114071, compound

HRID 2284336Notes

Reaction equation

HRID 2284336 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=1)[N:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:25][CH:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH2:28][CH2:27]1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:18]1[CH:19]=[CH:20][C:21]([NH:24][C:36](=[O:37])[C:35]3[CH:34]=[CH:33][C:32]([N:29]4[CH2:30][CH2:31][CH:26]([OH:25])[CH2:27][CH2:28]4)=[CH:40][CH:39]=3)=[CH:22][CH:23]=1)[N:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 86674029HCID 86674029, compound

Product 1

HCID 67114071HCID 67114071, compound

Procedure

Compound 988 was prepared according to the procedure described in Scheme IV from 5-benzyloxy-1-(4-aminophenyl)indazole and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C32H30N4O3: 519.23; found: 519.11.

Sources & evidence

ORD record
ord-7eda23c1d98c4ca481a05283eadc66a2
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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