4-Pyridinecarboxylic acid, 1-oxide → HCID 67113322, compound

HRID 2284340Notes

Reaction equation

HRID 2284340 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[C:18]([C:21]1[CH:26]=[CH:25][N+:24]([O-:27])=[CH:23][CH:22]=1)([OH:20])=O.[OH:28][CH:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:43]=[CH:42][C:38]([C:39](O)=[O:40])=[CH:37][CH:36]=2)[CH2:31][CH2:30]1>>[OH:28][CH:29]1[CH2:30][CH2:31][N:32]([C:35]2[CH:43]=[CH:42][C:38]([C:39]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:21]5[CH:26]=[CH:25][N+:24]([O-:27])=[CH:23][CH:22]=5)=[O:20])=[CH:13][CH:12]=3)[N:6]=[CH:5]4)=[O:40])=[CH:37][CH:36]=2)[CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 261304-Pyridinecarboxylic acid, 1-oxideHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 834142075-Amino-1-(4-aminophenyl)indazole

Product 1

HCID 67113322HCID 67113322, compound

Procedure

Compound 999 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-aminophenyl)indazole, 4-carboxypyridine 1-oxide, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C31H28N6O4: 549.12; found: 549.08.

Sources & evidence

ORD record
ord-9bbddac70c264ed8b99152701c32b5a0
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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