Ammonium formate → HCID 67466567, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-chloro-8-(pyridin-3-yl)imidazo[1,2-b]pyridazine (160 mg, 0.69 mmol) in EtOH (15 mL) was added ammonium formate (175 mg, 2.77 mmol) and palladium hydroxide on carbon (50 mg, 0.07 mmol) (20% wet) under nitrogen. The reaction mixture was heated to 50° C. for 20 min and cooled to room temperature. The reaction mixture was passed through a pad of CELITE® and washed with MeOH. The filtrate was concentrated and the residue was purified by BIOTAGE® (20-60% EtOAc/CH2Cl2, 1.5 L) to give the product (99 mg, 73%). LC (Condition B & C): >95% homogeneity index. LC/MS: Rt=0.31 min. LC/MS (Condition A): 197.21.

Provenance & Evidence