Ammonium formate → HCID 67466955, compound

Participants

Reaction Steps

A pressure bottle charged with a mixture of 4-(6-chloroimidazo[1,2-b]pyridazin-8-yl)isoquinoline (270 mg, 0.962 mmol), ammonium formate (243 mg, 3.85 mmol), palladium hydroxide on carbon (67 mg, 0.1 mmol) (20% wet), and EtOH (5 ml). The pressure bottle charged with a mixture of 4-(6-chloroimidazo[1,2-b]pyridazin-8-yl)isoquinoline (270 mg, 0.962 mmol), ammonium formate (243 mg, 3.85 mmol), palladium hydroxide on carbon (67 mg, 0.1 mmol) (20% wet), and EtOH (5 ml) was stirred at room temperature for 5 min. under nitrogen. The resulting mixture was heated to 50° C. for 20 min and cooled to room temperature. The reaction mixture was passed through a pad of CELITE® and washed with MeOH. The filtrate was concentrated and the residue was purified by BIOTAGE® (20-60% EtOAc/CH2Cl2, 1.5 L) to give the product (220 mg, 93%). LC/MS: Rt=0.54 min. LC/MS (Condition A): 247.17.

Provenance & Evidence