Hydrochloric Acid → HCID 73055947, compound

Participants

Reaction Conditions

Reaction Steps

To a 25 mL flask, tert-butyl (5-(6-fluoro-7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-yl)carbamate (0.06 g, 0.0001 mol) and 1,4-dioxane (4 mL) were added. The reaction mixture was cooled to 0° C. To the flask, 4 N HCl in 1,4-dioxane (6 mL) was added. The reaction mixture was stirred at room temperature for 12 hours. The volatiles were evaporated under reduced pressure to provide the crude product. The crude product was purified by preparative HPLC (10 mM ammonium acetate in water and acetonitrile) to provide the title compound (0.01 g, 7%). 1H NMR (400 MHz, DMSO-d6): δ 9.21 (s, 2H), 8.23 (s, 1H), 8.13-8.07 (m, 3H), 8.02 (d, J=11.2 Hz, 1H), 7.88 (t, J=8.0 Hz, 1H), 7.42 (br s, 2H), 3.96 (br s, 4H), 3.84 (br s, 4H), 3.43 (s, 3H): LC-MS (ESI): Calculated mass: 480.1; Observed mass [M+H]+: 481.1 (RT=0.30 min).

Provenance & Evidence