Dimethylformamide → HCID 86710178, compound

Participants

Reaction Steps

To a 50 mL round bottom flask, 4-(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-7-yl)benzoic acid (0.2 g, 0.00054 mol), cyclopropyl amine (0.046 g, 0.00081 mol) and DMF (10 mL) were added. To the same flask, HATU (0.3 g, 0.00081 mol) and TEA (0.23 mL, 0.0018 mol) were added. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was diluted with 10% methanol in chloroform and washed with water. The organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure to provide the crude product. The crude product was purified by flash column chromatography (0-1% methanol in chloroform) to provide the title compound (0.15 g, 68%). 1H NMR (300 MHz, DMSO-d6): δ 9.21 (d, J=2.4 Hz, 1H), 8.59 (d, J=4.2 Hz, 1H), 8.42 (d, J=2.4 Hz, 1H), 7.94-8.06 (m, 4H), 4.52 (br s, 4H), 3.80 (t, J=4.8 Hz, 4H), 2.88-2.90 (m, 1H), 0.60-0.62 (m, 2H), 0.70-0.73 (m, 2H): LC-MS (ESI): Calculated mass: 409.1; Observed mass [M+H]+: 410.1. (RT=1.34 min).

Provenance & Evidence