Pyridine → HCID 86710188, compound

Participants

Reaction Steps

To a 25 mL flask, tert-butyl (5-(7-(3-aminophenyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl)carbamate (Example 7, Step 2) (0.1 g, 0.0002 mol) and pyridine (4 mL) were added. To the same flask, 4-fluorobenzenesulfonyl chloride (0.038 g, 0.0002 mol) was added. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was diluted with 10% methanol in chloroform and washed with water. The organic layer was washed with brine, dried over sodium sulfate and was evaporated to provide the crude product. The crude product was purified by flash column chromatography (3% methanol in chloroform) to obtain the title compound (0.06 g, 45%). 1H NMR (300 MHz, DMSO-d6): δ 10.57 (s, 1H), 10.42 (s, 1H), 9.48 (s, 1H), 8.98 (d, J=2.1 Hz, 1H), 8.23 (d, J=2.1 Hz, 1H), 7.91 (dd, J′=5.1 Hz, J″=3.9 Hz, 2H), 7.65 (d, J=7.8 Hz, 1H), 7.56 (s, 1H), 7.45 (dd, J′=8.7 Hz, J″=1.5 Hz, 3H), 7.23 (d, J=7.8 Hz, 1H), 4.57 (br s, 4H), 3.83 (br s, 4H), 1.49 (s, 9H). LC-MS (ESI): Calculated mass: 658.2; Observed mass [M+H]+: 658.9 (RT=1.69 min).

Provenance & Evidence