Chloroacetyl chloride → HCID 86710189, compound

Participants

Reaction Conditions

Reaction Steps

To a 25 mL round bottom flask, tert-butyl (5-(7-(3-aminophenyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl)carbamate (Example 7, Step 2) (0.15 g, 0.0003 mol), chloroacetyl chloride (0.051 g, 0.00045 mol) and DCM (10 mL) were added and then cooled to 10° C. To the same reaction flask, triethylamine (0.12 mL, 0.0009 mol) was added. The reaction mass was stirred at room temperature for 30 minutes. The reaction mixture was diluted with DCM, washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and evaporated to provide the crude product. The crude product was purified by column chromatography (60-120 silica-gel and 0-2% methanol in chloroform) to afford the title compound (0.15 g, 87%). 1H NMR (300 MHz, DMSO-d6): δ 10.52 (s, 1H), 10.42 (s, 1H), 9.48 (s, 1H), 9.08 (d, J=1.8 Hz, 1H), 8.33 (d, J=2.1 Hz, 1H), 8.18 (s, 1H), 7.68 (t, J=4.8 Hz, 2H), 7.57 (t, J=7.8 Hz, 1H), 4.65-4.52 (br s, 4H), 4.33 (s, 2H), 3.84 (s, 4H), 1.49 (s, 9H): LC-MS (ESI): Calculated mass. 576.2, Observed mass [M+H]+: 577.2 (RT=1.53 min).

Provenance & Evidence