HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylboronic Acid → HCID 71778129, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylboronic Acid | HCID 139377 | — |
| Reactant | HCID 117678246 | HCID 117678246 | — |
| Reactant | HCID 117678406 | HCID 117678406 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 71778129 | HCID 71778129 | — |
Reaction Steps
Benzyl 4-chloro-2-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (see footnote 8) was reacted with methylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) to generate benzyl 2,4-dimethyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate; hydrogenolytic removal of the protecting group provided the requisite 2,4-dimethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145427B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-40372ce482d64168bdbaff2adfb883db |
| Source note | uspto-grants-2015_09 |