HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 7-Benzyl-2-cyclopropyl-5,6,7,8-tetrahydro-1,7-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-Chloro-1,7-naphthyridine | HCID 20696625 | — |
| Product | 7-Benzyl-2-cyclopropyl-5,6,7,8-tetrahydro-1,7-naphthyridine | HCID 117678253 | — |
Reaction Steps
2-Chloro-1,7-naphthyridine was subjected to a Suzuki reaction with cyclopropylboronic acid; the product was reacted with benzyl bromide, and then reduced with sodium borohydride to afford 7-benzyl-2-cyclopropyl-5,6,7,8-tetrahydro-1,7-naphthyridine. Protecting group removal with 1-chloroethyl carbonochloridate provided 2-cyclopropyl-5,6,7,8-tetrahydro-1,7-naphthyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145427B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-91741be09bab4ab3b6d38351e138ca54 |
| Source note | uspto-grants-2015_09 |