Acetamidine monohydrochloride → HCID 83846341, compound

HRID 2284449Notes

Reaction equation

HRID 2284449 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5](C(OCC2C=CC=CC=2)=O)[CH2:4][CH:3]1[C:18](=O)[CH2:19][CH3:20].Cl.[C:23](=[NH:26])([NH2:25])[CH3:24]>>[CH2:19]([C:18]1[C:3]2[CH2:4][NH:5][CH2:6][CH2:7][C:2]=2[N:25]=[C:23]([CH3:24])[N:26]=1)[CH3:20]

Participants

3

Reactant 2

HCID 67170Acetamidine monohydrochlorideHCID 117678218HCID 117678218, compound

Product 1

HCID 83846341HCID 83846341, compound

Procedure

Benzyl 4-oxo-3-propanoylpiperidine-1-carboxylate, prepared in similar manner to C28 in Example 6, was condensed with ethanimidamide hydrochloride; deprotection afforded the requisite 4-ethyl-2-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine.

Sources & evidence

ORD record
ord-c49c127a03fb4851bbf7177a93f6be28
Source dataset
uspto-grants-2015_09
Patent number
US09145427B2

Reaction notes

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