反应详情

Ethyl [7-(3-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate (116 mg, 0.36 mmol) was dissolved in dry dioxane (15 ml) and reacted with N-bromo succinimide (72 mg, 0.40 mmol) overnight at room temperature. The crude was dried under vacuo and purified on silica gel with Ethyl Acetate/Hexane 3/2 to give the wanted compound in quantitative yield.

1. customThe crude was dried under vacuo
2. custompurified on silica gel with Ethyl Acetate/Hexane 3/2
3. customto give the wanted compound in quantitative yield