HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Bromo-2-(chloromethyl)-4-iodobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Bromo-5-iodophenyl)methanol | HCID 53424372 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Bromo-2-(chloromethyl)-4-iodobenzene | HCID 59346328 | — |
Reaction Steps
Thionyl chloride (13 mL) is added to a suspension of 4-bromo-3-hydroxymethyl-1-iodo-benzene (47.0 g) in dichloromethane (100 mL) containing DMF (0.1 mL). The mixture is stirred at ambient temperature for 3 h. Then, the solvent and the excess reagent is removed under reduced pressure. The residue is triturated with methanol and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145434B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2818acd7b71c413684d8b92557468755 |
| Source note | uspto-grants-2015_09 |