HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2284464Generated: October 30, 2026
Water → 1-Bromo-4-iodo-2-(phenoxymethyl)benzene
https://huagongshe.com/reaction/2284464
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1-Bromo-2-(chloromethyl)-4-iodobenzene | HCID 59346328 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 1-Bromo-4-iodo-2-(phenoxymethyl)benzene | HCID 59346323 | — |
Reaction Steps
Phenol (13 g) dissolved in 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried (Na2SO4) and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09145434B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-3a4633eb786c4524b630bc7d514a5560 |
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| Source note | uspto-grants-2015_09 |
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