Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide | HCID 86661728 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile | HCID 86661729 | — |
반응 단계
To a solution of 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide (298 mg, 1 mmol) in acetonitrile (20 mL) was added POCl3 (460 mg, 3 mmol) and pyridine (474 mg, 6 mmol). After stirred at r.t for 2 hrs, the mixture was poured into aq. NaHCO3, extracted with EtOAc. The separated organics was dried and concentrated in vacuo to afford 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile. (300 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09145429B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-56f71123d6f04dca91f2ce32a39b6313 |
| 출처 메모 | uspto-grants-2015_09 |