HRID2284659

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](C(=O)Nc1cccc(N)c1)N(C)C(=O)OC(C)(C)C

HCID90051717

未命名化合物

结构：CCCNc1nc(Nc2ccc(C(N)=O)cc2)ncc1C(=O)O

HCID90051725

未命名化合物

PRODUCTS

生成物

结构：CCCNc1nc(Nc2ccc(C(N)=O)cc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)c1

HCID90051727

未命名化合物

PROCEDURE

实验过程

By using 2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxylic acid (C2) and (S)-tert-butyl (1-((3-aminophenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate (B9), (S)-tert-butyl (1-((3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate (C7) was obtained as white solid in the same manner as that of Example 7, (9).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c8917f29dbd040a8b6ec6e080f47626d
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09145415B2
来源说明: uspto-grants-2015_09

反应 SMILES

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([OH:23])=O)=[CH:13][N:12]=2)=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[NH2:24][C:25]1[CH:26]=[C:27]([NH:31][C:32](=[O:44])[C@@H:33]([N:35]([CH3:43])[C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH3:34])[CH:28]=[CH:29][CH:30]=1>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([NH:24][C:25]3[CH:26]=[C:27]([NH:31][C:32](=[O:44])[C@@H:33]([N:35]([CH3:43])[C:36](=[O:42])[O:37][C:38]([CH3:39])([CH3:41])[CH3:40])[CH3:34])[CH:28]=[CH:29][CH:30]=3)=[O:23])=[CH:13][N:12]=2)=[CH:8][CH:9]=1)(=[O:3])[NH2:2]