(S)-tert-butyl (1-((3-aminophenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate → (S)-tert-butyl (1-((3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

HRID 2284659Notes

Reaction equation

HRID 2284659 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([OH:23])=O)=[CH:13][N:12]=2)=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[NH2:24][C:25]1[CH:26]=[C:27]([NH:31][C:32](=[O:44])[C@@H:33]([N:35]([CH3:43])[C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH3:34])[CH:28]=[CH:29][CH:30]=1>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([NH:24][C:25]3[CH:26]=[C:27]([NH:31][C:32](=[O:44])[C@@H:33]([N:35]([CH3:43])[C:36](=[O:42])[O:37][C:38]([CH3:39])([CH3:41])[CH3:40])[CH3:34])[CH:28]=[CH:29][CH:30]=3)=[O:23])=[CH:13][N:12]=2)=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 90051717(S)-tert-butyl (1-((3-aminophenyl)amino)-1-oxopropan-2-yl)(methyl)carbamateHCID 900517252-((4-Carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxylic acid

Product 1

HCID 90051727(S)-tert-butyl (1-((3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Procedure

By using 2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxylic acid (C2) and (S)-tert-butyl (1-((3-aminophenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate (B9), (S)-tert-butyl (1-((3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate (C7) was obtained as white solid in the same manner as that of Example 7, (9).

Sources & evidence

ORD record
ord-c8917f29dbd040a8b6ec6e080f47626d
Source dataset
uspto-grants-2015_09
Patent number
US09145415B2

Reaction notes

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