Ethyl Acetate → HCID 90051729, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (2-((2-nitrobenzyl)oxy)ethyl)carbamate (C11, 154 mg) in ethanol (5 mL) and water (1 mL), iron powder (174 mg) and ammonium chloride (167 mg) were added at room temperature, and the mixture was stirred at 80° C. for 2 hours. The reaction mixture was cooled to room temperature, and then ethyl acetate was added to the reaction mixture. The insoluble matter was removed by filtration through Cerite, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by basic silica gel column chromatography (eluent, 75% hexane/25% ethyl acetate) to obtain oily tert-butyl (2-((2-aminobenzyl)oxy)ethyl)carbamate (C12, 60 mg).

Provenance & Evidence