(2-((3-Fluorophenyl)amino)-4-(propylamino)pyrimidin-5-yl)methanol → HCID 90051747, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2-((3-fluorophenyl)amino)-4-(propylamino)pyrimidin-5-yl)methanol (E13, 26 mg) in chloroform (2 mL), manganese dioxide (41 mg) was added at room temperature, and the mixture was stirred at 50° C. for 4 hours. The reaction mixture was cooled to room temperature, then the insoluble matter was removed by filtration through Cerite, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluent, 70 to 40% hexane in ethyl acetate) to obtain 2-((3-fluorophenyl)amino)-4-(propylamino)pyrimidine-5-carbaldehyde (E14, 26 mg).

Provenance & Evidence