Citric Acid → HCID 84014952, compound

Participants

Reaction Steps

To a solution of (E)-tert-butyl (2-(benzylideneamino)-2-methylpropyl)(methyl)carbamate (G9, 3.17 g) in tetrahydrofuran (25 mL), 5% aqueous citric acid (25 mL) was added at room temperature, and the mixture was stirred at the same temperature for 3 hours. To the reaction mixture, ethyl acetate and saturated aqueous sodium hydrogencarbonate were added. The organic layer was separated, and the aqueous layer was extracted with methylene chloride. The organic layer and the extract were combined, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluent, 100 to 0% hexane in ethyl acetate) to obtain tert-butyl (2-amino-2-methylpropyl)(methyl)carbamate (G10, 506 mg).

Provenance & Evidence