Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 90051776, compound

Participants

Reaction Steps

To a solution of (S)—N-(5-(2-((4-cyanophenyl)amino)-4-(pyrrolidin-1-yl)pyrimidin-5-yl)-4-pentyn-1-yl)-2-(methylamino)propanamide (H6) dihydrochloride (252 mg) and 4-dimethylaminocrotonic acid hydrochloride (331 mg) in N,N-dimethylformamide (8 mL), N-methylmorpholine (660 μL) and isobutyl chloroformate were added under ice cooling, and the mixture was stirred at the same temperature for 1 hour. To the reaction mixture, saturated aqueous sodium hydrogencarbonate (5 drop) was added, and the solvent was evaporated under reduced pressure. The obtained residue was purified by basic silica gel column chromatography (eluent, 100 to 90% ethyl acetate in methanol). The obtained solid matter was washed with a mixed solvent of ethyl acetate and hexane, and then dried under reduced pressure to obtain (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(pyrrolidin-1-yl)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide (9-1, 132 mg) as white solid.

Provenance & Evidence