Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of (S)-tert-butyl (1-((5-(2-chloro-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate (L1, 910 mg) in 1,4-dioxane (10 mL), a 4.0 mol/L solution of hydrochloric acid in dioxane (7 mL) was added at room temperature, and the mixture was stirred at the same temperature for 1 hour. The solvent was evaporated under reduced pressure to obtain (S)—N-(5-(2-chloro-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)-2-(methylamino)propanamide (L3) hydrochloride.

Provenance & Evidence