HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-Methyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)benzoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (S)-Methyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-phenoxy)methyl)benzoate | HCID 86720809 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-Methyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)benzoate hydrochloride | HCID 86720812 | 95% |
Reaction Steps
To a solution of (S)-Methyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-phenoxy)-methyl)benzoate (I12, 3.21 g, 7.20 mmol) in methanol (36 mL) was added hydrogen chloride in dioxane (4 M, 9.0 mL, 36 mmol). The reaction mixture was stirred at RT for 16 h. The solvent was removed in vacuo to afford (S)-Methyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)benzoate hydrochloride (2.65 g, >95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145409B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1d00a101e68f479cbca93cd828d009d8 |
| Source note | uspto-grants-2015_09 |