Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 3-Chloro-6-fluoro-[1,2,4]triazolo[4,3-a]pyridine | HCID 55267540 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 86687090 | HCID 86687090 | 46.1% |
Reaction Steps
A mixture of Intermediate 24b (515 mg, 3.00 mmol), pyrrolidine (0.85 g, 12.0 mmol) and DMA (10 mL) was heated to 175° C. for 4 h using microwave irradiation. After cooling, the solvent was removed in vacuo and the resulting residue purified by FCC, using 0 to 15% MeOH in DCM, to provide the title compound as a brown gum (285 mg, 26%). LCMS (Method 3): Rt 1.95 min, m/z 207 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09145413B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-49b46dca89364f93b7db6b3f3fb31ab3 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
