1-(2-Hydroxyethyl)piperazine → HCID 86687151, compound

Participants

Reaction Steps

A solution of Intermediate 24b (485 mg, 2.82 mmol) and 1-(2-hydroxylethyl)-piperazine (1.39 mL, 11.3 mmol) in DMA (10 mL) was heated in the microwave at 170° C. for 8 h. The cooled mixture was concentrated in vacuo. The residue was purified by FCC, using 0-20% (2M NH3 in MeOH) in DCM, to give impure product. Further purified by FCC, using 0-7% (2M NH3 in MeOH) in DCM gave the title compound as a pale brown gum (175 mg, 23%). LCMS (Method 3): Rt 0.43 min, m/z 266 [MH+].

Provenance & Evidence