Sodium Methoxide → HCID 70547308, compound

Participants

Reaction Steps

3.0 g 2-cyclopropyl-4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are mixed with a solution of 0.5 g sodium methylate in 30 ml methanol and stirred for three hours at room temperature. Then about 20 ml of methanol is distilled off. After adding water and extracting with chloroform, the organic phase is dried and concentrated. 1.9 g of 4-chloro-2-cyclopropyl-6-methoxy-5-(2-imidazolin-2-yl)-aminopyrimidine is obtained; melting point 214° C. The hydrochloride obtained in known manner has a melting point of 200° C.

Provenance & Evidence