HCID 20545076, compound → 4,6-Dichloro-2-cyclopropyl-5-pyrimidinamine

Participants

Reaction Steps

70 g of 2-cyclopropyl-4,6-dichloro-5-nitropyrimidine are hydrated in the presence of 8.2 g Raney nickel in 700 ml ethanol at 100 bar for 6 hours at room temperature. The reaction product is first extracted with methylenechloride, then the solution is concentrated, and the residue dissolved in cyclohexane and recrystallized. 41 g of 2-cyclopropyl-4,6-dichloro-5-amino-pyrimidine is obtained.

Provenance & Evidence