Methanol → HCID 70269420, compound

Participants

Reaction Steps

10.0 g 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are boiled in 400 ml methanol for 48 hours under reflux. The solution is concentrated, and the residue mixed with warm tetrahydrofuran. The crystals are recrystallized from isopropanol/ether. 6.4 g (80%) of 4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine is obtained as the hydrochloride, melting point 189° C. Melting point of the base 217°-219° C. (decomposition). 1H-NMR spectrum is DMSO-d6, delta values in ppm: 2.53 (s, CH3), 3.65 (s, N-CH2 --CH2 -N), 3.98 (s, OCH3), 8.66 (twice NH, deuterizable).

Provenance & Evidence