Sodium Methoxide → HCID 57255999, compound

HRID 2285523Notes

Reaction equation

HRID 2285523 reaction equation
Cl[C:2]1[C:7]([C:8]2[N:9](C(=O)C)[CH2:10][CH2:11][N:12]=2)=[C:6]([Cl:16])[N:5]=[C:4]([NH2:17])[N:3]=1.[CH3:18][O-:19].[Na+]>>[Cl:16][C:6]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:2]([O:19][CH3:18])[N:3]=[C:4]([NH2:17])[N:5]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 57319743HCID 57319743, compound

Product 1

HCID 57255999HCID 57255999, compound

Procedure

3.5 g 4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are introduced into 30 ml 1% sodium methylate solution. After three hours, the precipitate is vacuum dried, washed with water, and recrystallized from nitromethane. 2.1 g of 4-chloro-6-methoxy-5-(2-imidazolin-2-yl)-aminopyrimidine (melting point 212° C.), is obtained.

Workup

  1. customdried
  2. washwashed with water
  3. customrecrystallized from nitromethane

Sources & evidence

ORD record
ord-ae389cc49cb94a0093cd494e41dc1629
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

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