Sodium Hydroxide → HCID 13169284, compound

Participants

Reaction Steps

Into 81 ml of a 5% methanolic solution of sodium hydroxide, 20.0 g (0.084 mol) of ethyl 5-n-heptylpyrazole-3-carboxylate obtained in Example 1 was dissolved, and the solution was heated for 5 hours under a reflux condenser. After cooling the reaction mixture water was added, then methanol was distilled off under a reduced pressure, and the residue was acidified (pH of about 2) with concentrated hydrochloric acid. The deposited white precipitate was collected by filtration and recrystallized from a mixture of distilled water and methanol to obtain the object, 5-n-heptylpyrazole-3-carboxylic acid, as colourless needle-like crystals melting at 169°-171° C. in an amount of 13.3 g corresponding to the yield of 75.2%.

Provenance & Evidence