Diketene → HCID 178468092, compound

HRID 2285643Notes

Reaction equation

HRID 2285643 reaction equation
[NH:1]=[C:2]1[NH:6][C:5]([CH2:7][C:8]([NH:10][C@@H:11]2[C:23](=[O:24])[N:13]3[C:14]([C:20]([OH:22])=[O:21])=[C:15]([CH2:18][OH:19])[CH2:16][S:17][C@H:12]23)=[O:9])=[CH:4][S:3]1.[CH2:25]=[C:26]1[O:30][C:28](=[O:29])[CH2:27]1>>[NH:1]=[C:2]1[NH:6][C:5]([CH2:7][C:8]([NH:10][C@@H:11]2[C:23](=[O:24])[N:13]3[C:14]([C:20]([OH:22])=[O:21])=[C:15]([CH2:18][O:19][C:28](=[O:29])[CH2:27][C:26](=[O:30])[CH3:25])[CH2:16][S:17][C@H:12]23)=[O:9])=[CH:4][S:3]1

Participants

3

Reactant 2

HCID 12661DiketeneHCID 178509090HCID 178509090, compound

Product 1

HCID 178468092HCID 178468092, compound

Procedure

A process as claimed in claim 17, wherein 7β-[2-(2-imino-4-thiazolin-4-yl)acetamido]-3-hydroxymethyl-3-cephem-4-carboxylic acid or its salt is reacted with diketene to produce 7β-[2-(2-imino-4-thiazolin-4-yl)-acetamido]-3-(3-oxobutyryloxy)methyl-3-cephem-4-carboxylic acid or its salt.

Sources & evidence

ORD record
ord-f5f15f44718a441b91ce05c6a3bd1319
Source dataset
uspto-grants-1982_04
Patent number
US04323676

Reaction notes

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