N-(2-Hydroxyethyl)-4-nitrophthalimide → 5-Amino-2-(2-hydroxy-ethyl)-isoindole-1,3-dione

Participants

Reaction Steps

N-(2-Hydroxyethyl)-4-nitrophthalimide (30.0 g.), ethanol (300 ml.), and Raney nickel (3.0 g.) are mixed and hydrogenated at 100° C. and 1500 psi. until hydrogen uptake ceases. The hot solution is filtered to remove the Raney nickel and the solvent evaporated to yield 4-amino-N-(2-hydroxyethyl)-phthalimide, the amine which melts at 171°-173° C.

Provenance & Evidence