HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → 1-(2-dimethylaminoethyl)-3-phenylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(2-dimethylaminoethyl)-3-phenylurea | HCID 1526581 | — |
Reaction Steps
88 g of dimethylaminoethylamine are dissolved in 500 ml of toluene and then 119 g of phenyl isocyanate are added dropwise in the course of 10 minutes, whereupon the temperature rises to 97° C. The mixture is refluxed for 4 hours. On cooling, the product crystallises and is filtered with suction. The moist product is recrystallised from 1000 ml of ethyl acetate. Yield: 135 g (65.1%); m.p. 141°-142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04324739 |
| Source dataset | uspto-grants-1982_04 |
| ORD ID | ord-f20dd43691cb4951a4cef71cf71460f1 |
| Source note | uspto-grants-1982_04 |