2,2-Difluoropentanedioic acid → 2,2-Difluoroglutaric anhydride

HRID 2285685Notes

Reaction equation

HRID 2285685 reaction equation
[F:1][C:2]([F:11])([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[C:3](O)=[O:4]>C(OC(=O)C)(=O)C>[F:1][C:2]1([F:11])[CH2:6][CH2:7][C:8](=[O:10])[O:9][C:3]1=[O:4]

Participants

3

Reactant 1

HCID 204555012,2-Difluoropentanedioic acid

Product 1

HCID 539566372,2-Difluoroglutaric anhydride

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 5 g of 2,2-difluoroglutaric acid in 20 ml of acetic anhydride is refluxed for two hrs, 5 ml of the resulting solution is distilled off at ordinary pressure and the residual solution freed from acetic anhydride under reduced pressure. The resulting oil consists of 2,2-difluoroglutaric anhydride.

Workup

  1. distillation5 ml of the resulting solution is distilled off at ordinary pressure

Sources & evidence

ORD record
ord-263ceaab2cc84f93b3c131627ba57dc5
Source dataset
uspto-grants-1982_04
Patent number
US04324730

Reaction notes

Loading…