Methanol → 1-Methyl 2,2-difluoropentanedioate

HRID 2285686Notes

Reaction equation

HRID 2285686 reaction equation
[F:1][C:2]1([F:10])[CH2:8][CH2:7][C:6](=[O:9])[O:5][C:3]1=[O:4].[CH3:11][OH:12]>>[CH3:11][O:12][C:3](=[O:4])[C:2]([F:10])([F:1])[CH2:8][CH2:7][C:6]([OH:9])=[O:5]

Participants

3

Reactant 2

HCID 887MethanolHCID 539566372,2-Difluoroglutaric anhydride

Product 1

HCID 204555021-Methyl 2,2-difluoropentanedioate

Procedure

A solution of 3 g of 2,2-difluoroglutaric anhydride in 25 ml of dry methanol is allowed to remain at 25° for 18 hrs. At the end of this period the methanol is removed in vacuo leaving behind 2,2-difluoroglutaric 1-methyl ester as an oil.

Workup

  1. customAt the end of this period the methanol is removed in vacuo

Sources & evidence

ORD record
ord-f69b8127813f426db63310795be0c4cc
Source dataset
uspto-grants-1982_04
Patent number
US04324730

Reaction notes

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