Diethyl Ether → HCID 53839985, compound

HRID 2285709Notes

Reaction equation

HRID 2285709 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20].CC[O:23][CH2:24][CH3:25]>CO>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:25][C:24]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1])=[O:23]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 16402HexamethylenediamineHCID 109094Ethyl 2-oxopyrrolidine-1-acetate

Product 1

HCID 53839985HCID 53839985, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g (0.06 mol) of ethyl 2-oxo-1-pyrrolidineacetate and 3.4 g (0.03 mol) of 1,6-diaminohexane are dissolved in 5 ml of absolute methanol and the solution is boiled for 19 hours, moisture being excluded. Ether is added to the solution and the precipitate which separates out is filtered off. The product is purified by chromatography on silica gel from methanol:water (100:25).

Workup

  1. filtrationthe precipitate which separates out is filtered off
  2. customThe product is purified by chromatography on silica gel from methanol:water (100:25)

Sources & evidence

ORD record
ord-cb8faaca647f41e79e91aa902a44508b
Source dataset
uspto-grants-1982_04
Patent number
US04324787

Reaction notes

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