2,2,4-Trimethyl-1,6-hexanediamine → HCID 20544070, compound

Participants

Reaction Steps

8.55 g (0.05 mol) of ethyl 2-oxo-1-pyrrolidineacetate and 3.95 g (0.025 mol) of 2,2,4-trimethyl-1,6-diaminohexane are boiled in 5 ml of absolute methanol for 22 hours, moisture being excluded. After evaporating off the solvent, the residue is chromatographed on silica gel from methanol/water (80:30). Chromatography is then carried out a second time from methanol/water/acetic acid (20:7.5:2.5), and finally the water and the acetic acid are removed by chromatography on aluminium oxide. The product is syrupy with nD54 1.5095.

Provenance & Evidence