2,4,5-Trichlorophenol → HCID 20544060, compound

HRID 2285712Notes

Reaction equation

HRID 2285712 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([OH:10])=[O:9].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[C:15]([Cl:19])=[CH:14][C:13]=1O.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10][C:13]1[CH:14]=[C:15]([Cl:19])[C:16]([Cl:18])=[CH:17][C:12]=1[Cl:11])=[O:9]

Participants

5

Reactant 3

HCID 72712,4,5-TrichlorophenolHCID 10868DicyclohexylcarbodiimideHCID 31466872-(2-Oxopyrrolidin-1-yl)acetic acid

Product 1

HCID 20544060HCID 20544060, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

84.8 g of 2-oxo-1-pyrrolidineacetic acid and 128.5 g of 2,4,5-trichlorophenol are dissolved in 1,500 ml of methylene chloride, 138.75 g of dicyclohexylcarbodiimide are slowly added at 0° C. and the mixture is stirred at 20° C. for three hours. The urea which has precipitated is then filtered off, the solvent is evaporated off and the residue is recrystallised from ethyl acetate.

Workup

  1. customThe urea which has precipitated
  2. filtrationis then filtered off
  3. customthe solvent is evaporated off
  4. customthe residue is recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-2ef2892c807041a287a8ea6e2c3d1623
Source dataset
uspto-grants-1982_04
Patent number
US04324787

Reaction notes

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