2-Chloro-N,N-dimethylethylamine → HCID 13019471, compound

Participants

Reaction Steps

A solution of 4-cyanomethylbenzoic acid, methyl ester (28.8 g) in dry dimethylformamide (DMF) (100 ml) was added dropwise to a stirred suspension of sodium hydride (80%, dispersion in oil, 5.4 g) in DMF (50 ml) under nitrogen. The mixture was stirred at 50° for 1 h., then a solution of dimethylaminoethyl chloride (21.3 g) in DMF (50 ml) was added and stirring was continued at 50° for 18 h.

Provenance & Evidence